Barcelona forward Lionel Messi will be out for between six and eight weeks with a hamstring injury, the La Liga leaders said on Monday.
City were given a stern test on a wet and windy night at a noisy Kassam Stadium but two goals from Raheem Sterling eventually saw them through.
Among other transfer news globally, defender Rahul Bheke joins Mumbai City FC while Locatelli completes Juventus move.
German international Ilkay Gundogan scored twice and was at the heart of City's hugely impressive display as Pep Guardiola's side delivered the kind of football that took them to title wins in 2018 and 2019.
Barring a monumental collapse Manchester City will win at least two trophies this season, but former England captain Alan Shearer believes European bragging rights are what the club's Abu Dhabi owners crave most.
Bayern Munich eased into the German Cup semi-finals with a 3-0 victory over 10-man VfL Bochum on Wednesday with Robert Lewandowski scoring twice to keep their treble hopes on track.
Manchester City's long winning run in the Premier League finally came to an end
News of all that's transpired on and off the football field.
Manchester City failed to fire in a frustrating 0-0 home draw with StokeCity on Wednesday that dealt a damaging blow to their Premier League title hopes and left them 10 points adrift of leaders Chelsea.
'Soul might not win trophies. But, unlike trophies, soul actually matters,' says Shougat Dasgupta.
Brazil have sacked manager Luiz Felipe Scolari just hours after the end of a home World Cup in which they suffered two of their worst defeats in the tournament's history, one of Brazil's leading newspapers reported on Monday.
A summary of Wednesday's action in the Premier League.
Kevin de Bruyne struck twice to inspire Manchester City to a dominant 4-2 win at Crystal Palace on Saturday and move the champions level on points with Liverpool at the top of the Premier League table.
The league has ruled out a 'pause' to the season to allow clubs to recover their squads, although the surging Omicron variant has put paid to half of the weekend's fixtures including Manchester United's home game with Brighton & Hove Albion.
Bayern Munich and Atletico Madrid made it four away wins from the opening four Champions League last-16 first leg matches when they triumphed at Arsenal and AC Milan respectively on Wednesday.
A weakened Manchester United were beaten 2-1 at home by Leicester City on Tuesday, ending Manchester City's wait to be crowned Premier League champions.
Manuel Pellegrini has said he would choose winning the Premier League with Manchester City and being shown the door over continuing as the team's manager for an extended period without any major success.
Liverpool may have to wait a little longer for their Premier League title celebrations after they were held to a 0-0 draw at Everton in the behind closed-doors Merseyside derby on Sunday.
A preview of the line-up action in the English Premier League
Manchester City will attempt to overturn their two-year UEFA ban from European football when a three-day hearing at the Court of Arbitration for Sport in Switzerland begins on Monday. European soccer's governing body UEFA ruled in February that City had committed serious breaches of Financial Fair Play (FFP) regulations and failed to cooperate with its investigation, handing them a ban and a 30 million euro (24.9 million pounds) fine.
News of all that's transpired on and off the football field
Barca made a slow start to the campaign under their new coach but after beating Paris Saint Germain in the quarter-finals they are on course to repeat the treble success.
Real are on 81 points with four games to go. They are 17 points ahead of nearest rivals Sevilla.
Champions Manchester City have won their last 10 home league matches scoring a total of 36 goals.
Darwin Nunez came off the bench to score twice as Liverpool snatched a sensational 2-1 Premier League win at Newcastle United on Sunday.
PSG's Champions League tie with Newcastle is like a final, says Luis Enrique
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Manchester City's bid to chop Arsenal's Premier League lead to two points was scuppered as Harry Kane's record-breaking goal earned Tottenham Hotspur a 1-0 win.
Substitute Moussa Dembele scored twice as Olympique Lyonnais stunned Manchester City on Saturday to move into the semi-finals of the UEFA Champions League.
Bayern Munich's smooth passage into the Champions League knockout stage hit a speed bump after it emerged on Thursday that versatile Austria international David Alaba will need knee surgery and will be out for several weeks.
Images from Saturday's action in the Premier League.
'For the Premier League, it would be great having the best player in the world in the league. I'm not sure the Premier League needs a boost but it would be.'
Manchester City moved back into third place and almost guaranteed Champions League qualification thanks to a 3-1 home victory against West Bromwich Albion on Tuesday at the Etihad Stadium.
Hazard, who will face his former manager when Chelsea host United in the league next Saturday, admitted he made a complacent start to that campaign.
Manchester City barely got out of second gear as they easily beat bottom club Huddersfield Town to close the gap on Premier League leaders Liverpool to four points on Sunday.
Liverpool finished 2016 second in the Premier League with a 1-0 victory over third-placed Manchester City on Saturday.
Liverpool boss Juergen Klopp has beaten Manchester United only twice in his career and never at Old Trafford -- his worst record against any Premier League side.
Rafael Nadal has issued a rallying cry and called on Spanish athletes to help raise 11 million euros ($12.07 million) to help fight the coronavirus pandemic. Spain is one of the most badly affected countries in the world with over 56,000 cases and the parliament voted to extend the coronavirus lockdown to at least April 12 after the death toll rose to over 4,000 by Thursday.
Diaz double puts City in quarters, De Bruyne injured
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